ACTH (1-39), human

CAS No. 12279-41-3

ACTH (1-39), human ( Adrenocorticotropic Hormone (ACTH) (1-39), human )

Catalog No. M29942 CAS No. 12279-41-3

Adrenocorticotropic hormones (ACTH). ACTH stimulates the adrenal cortex and the secretion of glucocorticoids such as cortisol.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 266 In Stock
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25MG 1017 In Stock
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Biological Information

  • Product Name
    ACTH (1-39), human
  • Note
    Research use only, not for human use.
  • Brief Description
    Adrenocorticotropic hormones (ACTH). ACTH stimulates the adrenal cortex and the secretion of glucocorticoids such as cortisol.
  • Description
    Adrenocorticotropic hormones (ACTH). ACTH stimulates the adrenal cortex and the secretion of glucocorticoids such as cortisol.(In Vitro):Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH 1-39), a member of the melanocortin family, stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and on immune cells. ACTH 1-39 protects neurons in vitro from several apoptotic, excitotoxic and inflammation-related insults. The conditioned medium (CM) is prepared from untreated astroglia (AS) cultures and from AS cultures treated with 200 nM ACTH 1-39 for 24 h, washed to remove ACTH 1-39, then incubated for another 24 h in DMEM. In initial experiments, no difference is found in oligodendroglia (OL) viability in the presence of OL definedmediumwith 2% newborn calf serum (NCS) or AS CM (prepared in DMEM with no serum). After 24 h, OL death under each condition varies between 1 and 4%. Similar results for OL viability are obtained with microglia (MG) CM. In subsequent experiments, controls in each experiment consist of OL in defined medium with 2% NCS.
  • Synonyms
    Adrenocorticotropic Hormone (ACTH) (1-39), human
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    12279-41-3
  • Formula Weight
    4541.1
  • Molecular Formula
    C207H308N56O58S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Lisak RP, et al. Melanocortin receptor agonist ACTH 1-39 protects rat forebrain neurons from apoptotic, excitotoxic and inflammation-related damage. Exp Neurol. 2015 Nov;273:161-7.
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